Topic 7. Toxicology of Chemotherapeutic Agents and Antibiotics

Lecture



Topic 7. Toxicology of chemotherapeutic agents.
Chemotherapeutic agents. Antibiotics. Classification. Dose range. Toxicodynamics.
Toxicokinetics. Mechanism of toxic action. Factors that increase and decrease toxicity.
Therapy of acute poisoning.
Sulfonamide drugs. Antibacterial drugs of various chemical structures. Classification.
Dose range. Toxicodynamics. Toxicokinetics. Mechanism of toxic action. Factors that increase
and decrease toxicity. Therapy of acute poisoning.
Antituberculosis, antisyphilitic, and antiviral agents. Classification. Dose range.
Toxicodynamics. Toxicokinetics. Mechanism of toxic action. Factors that increase and
decrease toxicity. Therapy of acute poisoning.
Antifungal and anthelmintic agents. Classification. Dose range. Toxicodynamics.
Toxicokinetics. Mechanism of toxic action. Factors that increase and decrease toxicity.
Therapy of acute poisoning.
Antitumor (antiblastoma) agents. Classification. Dose range. Toxicodynamics.
Toxicokinetics. Mechanism of toxic action. Factors that increase and decrease toxicity.
Therapy of acute poisoning.

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Lectures and tutorial on "Toxicology"

Terms: Toxicology

Introduction to Toxicology
1.1+ Subject of General Toxicology, Objectives, Basic Concepts and Terminology
1.2. Research Methods in Toxicology
1.3+. Basic Toxicological Characteristics
1.4+. Classification of Poisons in Toxicology
2.1.+ Absorption, Biotransformation and Excretion of Harmful Substances in the Biological Organism
1.1. Toxicokinetics of Poisons: Poisons and Their Classification
1.2. Distribution of Poisons in the Body
1.3. Binding of Poisons in the Body
1.4. Factors Affecting the Toxicity of Chemical Compounds
1.5. Methods of Detoxification
1.6. Metabolism of Foreign Compounds
1.7. Conjugation Processes
3+. Repeated Exposure of the Body to Harmful Substances
4+. Calculation Methods for Determining Maximum Permissible Concentrations of Substances in the Air of the Working Zone
5+. Toxicology of Radioactive Substances
6+. Ecological Toxicology: Intoxication by Mercury, Carbon Monoxide, Hydrogen Sulfide and Carcinogens; Detoxification
2.1. Toxicology of Food Contamination by Nitrates
2.2. Radiation Contamination and Radiation Processing of Food Products
2.3. Contamination of Food Products and Raw Food Materials by Pesticides
2.4. Contamination of Food Products and Raw Food Materials by Heavy Metals
3.1 Hygienic Principles of the Use and Functions of Food Additives
3.2. Classification of Food Additives
3.3. Safety of Food Additives
3.4. Toxicology of Food Colorants
3.5. Toxicology of Aromatic Substances
3.6. Toxicology of Flavor and Aroma Enhancers
3.7. Toxicology of Sweeteners and Sugar Substitutes
3.8. Toxicology of Food Acidity and Alkalinity Regulators
3.9. Toxicology of Food Stabilizers, Thickeners, Chelating Agents, and Gelling Agents
3.10. Toxicology of Food Preservatives
3.11. Toxicology of Food Antioxidants
4.1. Toxicology of Fatty Acids, Alcohols, and Waxes in Perfumery and Cosmetic Products
4.2. Toxicology of Surfactants, Emulsifiers, and Wetting Agents in Perfumery and Cosmetic Products
4.3. Toxicology of Preservatives in Perfumery and Cosmetic Products
4.4. Toxicology of Fragrances and Scent Fixatives
4.5. Toxicology of Colorants in Perfumery and Cosmetic Products
4.6. Toxicology of Skin-Whitening Agents
4.7. Toxicology of Mineral Oils in Perfumery and Cosmetic Products
Introduction to Drug Toxicology (Pharmacotoxicology). General Concepts
2. Predicting the Toxicity of Drugs. Stages of Development. Classification of Preclinical Studies
3. Mechanisms of the Toxic Action of Drugs. Principles of Body Detoxification in Poisoning
4. Toxicology of Neurotransmitter-Acting Drugs, Opioid and Non-Opioid Analgesics, and NSAIDs
5. Toxicology of Sedatives, Psychostimulants, Antidepressants, Analeptics, Nootropics, and Adaptogens
6. Toxicology of Drugs Affecting Metabolism, Blood, and the Cardiovascular System, and of Antihistamines
Topic 7. Toxicology of Chemotherapeutic Agents and Antibiotics
Introduction to Forensic Toxicology
Forensic Medical Toxicology. Poisons: General Concept, Classification, and Specific Effects on the Body
Forensic Medical Toxicology. Poisoning by Specific Toxic Substances
Toxicological Chemistry (Analytical and Biochemical Toxicology)
Terms and Concepts of Analytical Toxicology. Objectives of Toxicology. Chemical-Toxicological Analysis